Dr. Patricia Wadsworth
University of Massachusetts
Amherst, MA, USA
Specimen: Mitotic Spindle
While the spindle apparatus is composed of hundreds upon hundreds of proteins,the fundamental machinery are the spindle microtubules. Attachment of microtubules to chromosomes is mediated by kinetochores, which actively monitor spindle formation and prevent premature anaphase onset. Microtubule polymerization and depolymerization dynamics drive chromosome congression. Depolymerization of microtubules generates tension at kinetochores, bipolar attachment of sister kinetochores to microtubules emanating from opposite cell poles couples opposing tension forces, aligning chromosomes at the cell equator and poising them for segregation to daughter cells. Once every chromosome is bi-oriented, anaphase commences and cohesin, which couples sister chromatids, is severed, permitting the transit of the sister chromatids to opposite poles.
Delivering drugs right to the heart of cancerous tumours is a challenging task. They must reach their dangerous target – which may be deep within tissues – without alerting immune cells that police the body for foreign invaders. Scientists are now tackling this predicament by camouflaging drugs in nanoparticles coated with membranes from leukocytes [white blood cells]. Unlike naked nanoparticles, these tiny disguised pouches raise no suspicion. And what’s more they behave like white blood cells, using their borrowed membranes en route to wriggle through barriers, such as blood vessels, as they home in on their target. Such coated particles, known as ‘leukolike vectors’ bring the prospect of more effective treatment for previously inaccessible cancers.
Written by Georgina Askeland
Dr. Michael Bridge
University of Utah School HSC Core Facilities - Cell Imaging Lab,
Salt Lake City, Utah, USA
Specimen: Eye organ of a Drosophila melanogaster (third-instar larvae) (60x)
Band-Aid Post-It Notes. Tell me this isn’t the least bit cool. It’s also around $3.00 on eBay.
Medical Journey’s Book Giveaway:
I’ve decided to do a holiday book giveaway this year to share some of my favorite medically relevant books with a few of my followers. I will be giving away the following books (completely free, I will cover shipping):
1. On Call: A Doctor’s Days and Nights in Residency by Dr. Emily R. Transue
2. Complications: A Surgeon’s Notes on an Imperfect Science by Dr. Atul Gawande
3. The Intern Blues: The Timeless Classic About the Making of a Doctor by Dr. Robert Marion
4. How Doctors Think by Dr. Jerome Groopman
I will be doing a random drawing to pick 4 winners who will receive one book each.
To enter, just re-blog this post. Please re-blog only once. I will assign a number to everyone who re-blogs this post. If you are the 1st person to reblog, you will be #1 and so on. At the end of the giveaway I will draw 4 numbers using random.org to pick the winners. You can enter until December 15th. At 9 PM Eastern Time on December 15th I will announce the 4 winners. Message me with any questions!
Aufbau des Knochens
Das knöcherne Skelett bildet das Stützsystem des Körpers. Es stellt ein großes Mineralreservat (Kalziumionen) dar, dient der Muskulatur als Ansatzfläche und schützt innere Organe. Wie kein anderes Gewebe adaptiert sich der Knochen (Masse und Morphologie) an funktionelle Anforderungen. Er repariert sich selbst, ohne eine “Narbe” zu hinterlassen und kann (bei Kindern) selbst Fehlstellungen nach einem Bruch ausgleichen.
|—||~Edwin Powell Hubble, The Nature ofScience, 1954 (via sciencenote)|
Getting the Nerve
The primary function of hair is to keep mammals at ~37°, but it also plays a key sensory role. Nerve receptors in hair follicles can sense displacements and vibrations of the hair shafts, making them extremely sensitive to touch. Ginty and colleagues recently developed a tool to visualize mechanosensory neurons in hair follicles. They found that each type of hair follicle is innervated by a unique combination of mechanosensory neurons, making each type of hair—from the thin ones on your arm to the thick ones on your head,— is a functionally distinct mechanosensor.
Image: Here the complex pattern of mechanosensory neuron encircling a guard hair follicle (i.e., the thick hair on the back of mice) is imaged with confocal microscopy (left). Nerve terminals expressing neurofilament 200 (NF200) are purple, whereas those expressing Npy2r-GFP are green. Double-positive fibers are white. In the inset, the neurons (red) in one hair follicle are activated by touch.